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The effect of pretreatment with glutamate system modulator on hyperforin activity in the TST in mice. NMDA (75 mg/kg; i.p.) was administered 15 min before hyperforin (2.5 mg/kg; i.p.). TST was carried out 60 min after hyperforin administration. **p < 0.01 vs. control, #p < 0.05 vs. hyperforin, n = 5–7; [F(3, 22) = 4.957; p = 0.0089]. All data was analyzed by one-way ANOVA and Newman-Keuls multiple comparisons test. All values are expressed as mean ± S.E.M.
