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Effects of hyperforin/Lanicemine on layer V to later II/III NMDA synaptic transmission. (A,B) Application of Lanicemine markedly reduced the NMDA current, whereas hyperforin had no effect (p = 0.0313, median 51.63%, n = 6 vs. p = 0.8750, median 94.8, n = 4, respectively, Wilcoxon Signed Rank Test), *p < 0.05 vs. Hyp. Below, (C) Sample raw NMDA currents recorded under the two conditions, dotted line is for baseline currents.
