Skip to main content
. 2018 Dec 12;11:456. doi: 10.3389/fnmol.2018.00456

Figure 7.

Figure 7

The effect of the administration of single doses of hyperforin (Hyp), lanicemine (Lan) and hyperforin + lanicemine (Hyp + Lan) on the expression of p-CREB, total CREB, BDNF, Synapsin I, and GluA1 subunit of AMPA receptors. (A) Experimental schedule of drug treatments. (B) Representative blots. (C–F) lanicemine (10 mg/kg) was administered 90 min and hyperforin (2.5 mg/kg) 60 min before TST. (G) Experimental schedule of drug treatments. (H) Representative blots. (I–L) lanicemine was administered 72.5 h and hyperforin 72 h before TST. Frontal cortex was dissected immediately after TST. (C) p-CREB/CREB [F(3, 28) = 0.4795; p = 0.6992]. (D) BDNF, [F(3, 28) = 4.886; p = 0.0074]. (E) Synapsin I, [F(3, 24) = 3.573; p = 0.028]. (F) GluA1 [F(3, 28) = 3.656, p = 0.0243]. *p < 0.05 vs. control, **p < 0.01 vs. control, #p < 0.05 vs. Hyp + Lan, $p < 0.05 vs. Hyp + Lan. Effects observed 72 h after treatment: (I) p-CREB/CREB, [F(2, 20) = 2.734; p = 0.0892]. (J) BDNF [F(2, 21) = 3.764; p = 0.0401]. (K) Synapsin I, [F(2, 21) = 0.2062; p = 0.8153]. (L) GluA1, [F(2, 21) = 0.3509; p = 0.7081]. *p < 0.05 vs. control. All data was analyzed by one-way ANOVA and Newman-Keuls multiple comparisons test. All values are expressed as mean ± S.E.M.