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. 2018 Dec 18;3:34. doi: 10.1038/s41525-018-0072-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Trisomy detection under in vitro conditions. Boxplots over applied UMI thresholds of normalized molecule counts (y-axis) of trisomy TAC-seq experiments indicates a positive correlation between the trisomy factor (x-axis, trisomic cell proportion) and chr21 counts. Experiment 1, upper four plots, involved 114 loci along chr2 and chr21. One biological replica is depicted. Experiment 2, lower four plots at various UMI thresholds, involved extended TAC-seq probe set (in total 224 probes) along chr2, chr3, and chr21. The red asterisks indicate significant reference chromosome(s) and chr21 read-count-based differences between studied samples (p < 0.05, one-tailed Welch’s t-test)