Table 3.

Interaction analysis of the signature and chemotherapy in relationship with PFS using multivariate Cox proportional hazards regression

	Training set (n = 67)		Internal testing set (n = 40)		Independent validation set (n = 44)
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Response to chemotherapy (CR + PR + SD vs PD)	3.103 (1.436–6.708)	0.004	10.263 (3.463–30.413)	<0.001	2.802 (1.276–6.152)	0.010
miRNA signature (low vs high risk)	2.817 (1.584–5.009)	< 0.001	7.797 (2.525–24.089)	<0.001	3.153 (1.444–6.887)	0.004
Interaction	3.644 (1.528–8.690)	0.004	8.426 (2.592–27.390)	<0.001	2.653 (1.031–6.829)	0.043