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. 2018 Dec 18;9:5368. doi: 10.1038/s41467-018-07806-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — IL-2 makes substantial modifications in the epigenetic landscape of T_reg cells: T_reg cells (5 × 10⁴) were sorted by flow cytometry from thymus or LNs of Il2ra^mut/mut and WT Foxp3^Rfp/Rfp reporter mice, lysed and DNA from nucleus extracted for analysis of open chromatic regions by ATAC-seq. a Venn diagram of number of common and unique ATAC-seq peaks (OCRs) in Il2ra^mut/mut vs WT T_reg cells from thymus and LNs. b, c Distribution of common and unique ATAC-seq peaks across gene organization (b) and distance to the transcription start site (TSS, c) in the whole genome. d, e Venn diagrams of number of genes (d) and GO pathways (e) exhibiting unique peaks in Il2ra^mut/mut vs WT thymic and LN T_reg cells on all (d) or within (e) 20 kb from TSS. f Network analysis of biological-process GO term enrichment among genes with unique peaks within 20 kb from TSS in Il2ra^mut/mut or WT thymic and LN T_reg cells. Genes were analyzed for over-represented GO terms using ReviGO. Node color is proportional to the FDR-adjusted p-value of the enrichment. Node size is proportional to gene set size