Table 4.

Ranking of genes in positive selection brefeldin A screen using MAGeCK

Rank	Gene	Number of sgRNAsa	RRA scoreb	p c	FDR	Good sgRNAs	LFCd
1	ARF4	6	1.05E−19	2.29E−07	0.00495	6	10.185
2	OGFRL1	5	2.58E−05	3.50E−05	0.378713	2	−4.953
3	hsa-mir-4676	3	0.00013943	0.00015396	0.725548	1	−7.014
4	hsa-mir-106a	4	0.00014459	0.00016952	0.725548	1	−5.515
5	CCDC33	6	0.00015492	0.00018233	0.725548	1	−4.149
6	EDN3	5	0.00028401	0.00029488	0.725548	1	−3.398
7	ANKRD35	6	0.00040275	0.00042939	0.725548	1	−4.256
8	NonTargeting	1	0.00042864	0.00043443	0.725548	1	6.0675
9	NonTargeting	1	0.00048029	0.00048521	0.725548	1	5.6036
10	ACAP1	6	0.00052665	0.0005424	0.725548	1	−5.284

^aNumber of sgRNAs refers to number of sgRNAs targeting the gene

^bRRA score is derived from a robust ranking aggregation (RRA) algorithm that determines the degree of consistency seen in the enrichment of multiple sgRNAs targeting a particular gene, compared to sgRNAs targeting other genes

^cp Value is generated for these RRA scores

^dLFC is log fold change of sgRNAs