Skip to main content

View full-text article in PMC

. 2018 Dec 18;9:5360. doi: 10.1038/s41467-018-07199-6

Table 2.

Half-effective dosage (ED₅₀) of double-type and triple-type chimeras in mice

Antigen category	HPV VLP	ED₅₀ (μg)
Antigen category	HPV VLP	anti-HPV33	anti-HPV58	anti-HPV52
Wild-type control	HPV33	0.066^a	> 0.3	—
	HPV58	> 0.3	0.006	—
Double-type chimera	H33-58HI	0.053	0.049	—
	H58-33BC	0.043	0.019	—
Wild-type control	HPV33	0.013^b	>0.3	>0.3
	HPV58	> 0.3	0.021	>0.3
	HPV52	>0.3	>0.3	0.046
	H33&58&52	0.009	0.009	0.017
Triple-type chimera	H33-58HI-52DE	0.083	0.069	0.557
	H33-58HI-52FG	0.046	0.243	0.087
	H58-33BC-52DE	0.009	0.014	0.341
	H58-33BC-52HI	0.065	0.058	0.041

^aRefer to the detailed ED50 calculation in Supplementary Table 4

^bRefer to the detailed ED50 calculation in Supplementary Table 5