Table 2.

Primary analyses for the association of UCLA-loneliness with entorhinal cortical FTP binding, and inferior temporal cortical FTP binding

		Dependent variable: UCLA-loneliness scale
		Left entorhinal cortex model	Right entorhinal cortex model	Left inferior temporal cortex model	Right inferior temporal cortex model
Age	β	−0.40	−0.46	−0.36	−0.45
	SE	(0.20)	(0.19)	(0.20)	(0.20)
	p-value	0.047*	0.018*	0.074	0.029*
Sex	β	0.04	0.15	0.02	0.07
	SE	(0.38)	(0.37)	(0.39)	(0.38)
	p-value	0.913	0.682	0.954	0.851
APOEε4 carrier status	β	−0.29	−0.53	−0.22	−0.38
	SE	(0.43)	(0.43)	(0.43)	(0.43)
	p-value	0.500	0.215	0.605	0.378
FTP binding	β	0.56	1.37	0.33	1.56
	SE	(0.58)	(0.52)	(1.01)	(1.03)
	p-value	0.337	0.010*	0.743	0.135
	95% BCa CI	[−0.61, 1.51]	[0.28, 2.15]	[−1.78, 1.89]	[−0.62, 3.59]
	Cohen’s f2	0.093	0.254	0.032	0.146
	Model adjusted R2	0.003	0.055	−0.005	0.015

Four models show the association of FTP binding in four a priori regions of interest with scores for the UCLA-loneliness scale, controlling for age, sex, and APOEε4 carrier statu. Statistics are presented as unstandardized estimate coefficient (β), standard error of the mean (SE), and p-value. Covariates were centered. p* < 0.05

APOEε4 apolipoprotein E e4, FTP flortaucipir, BCa CI bias-corrected and accelerated bootstrapped confidence interval