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. 2018 Dec 12;9:2844. doi: 10.3389/fimmu.2018.02844

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Copyright © 2018 Zhang, Xu, Zhang, Hu, Luo, Han, Li and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of GB on the ultrastructure of myocardial tissue, histopathological changes, histopathological scores, PMNs counting, MPO activity and ICAM-1, VCAM-1, iNOS expressions in MI/RI rats model. (A1–5) Representative transmission electron microscopy (TEM) observation of myocardial tissue injury for control group (A1), I/R group (A2), I/R + 8 mg/kg GB group (A3), I/R + 16 mg/kg GB group (A4), I/R + 32 mg/kg GB group (A5). (B1-5) Representative light microscopic appearance of rat myocardial histopathological morphology (HE staining; original magnification × 200) for control group (B1), I/R group (B2), I/R + 8 mg/kg GB group (B3), I/R + 16 mg/kg GB group (B4), I/R + 32 mg/kg GB group (B5). (C) Effect of GB on histopathological scores, (D) effect of GB on myocardial PMNs counting, (E) effect of GB on MPO activity, effect of GB on expressions of ICAM-1, VCAM-1, iNOS (F) and effect of GB on expression of A20 (G). The location of the histological images were taken in three random fields of infarcted area. Data were expressed as mean ± S.D. (n = 8). ^##P < 0.01, I/R group vs. control group; *P < 0.05, **P < 0.01, 8, 16, 32 mg/kg GB groups vs. I/R group.