Table 2.
Inter-individual analysis of CBV distributions across brain regions and sleep states
| CORTEX | QW | NREM | AW | REM | REM-TONIC | REM-PHASIC | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Animal | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | ||||||
| Rat1 (7) | 0.1 | −0.3 | 0.4 | - | 1.6 | 1.2 | 2.0 | 0.00 | 4.5 | 3.2 | 5.7 | 0.00 | 13.3 | 10.8 | 15.9 | 0.00 | 7.5 | 5.9 | 9.2 | 0.00 | 26.8 | 22.7 | 30.9 | 0.00 |
| Rat2 (7) | −0.2 | −0.8 | 0.4 | - | −2.7 | −3.0 | −2.4 | 0.00 | 3.3 | 1.6 | 5.0 | 0.00 | 10.0 | 8.2 | 11.9 | 0.00 | 4.7 | 3.0 | 6.3 | 0.00 | 17.2 | 14.3 | 20.2 | 0.00 |
| Rat3 (9) | 0.6 | 0.1 | 1.0 | - | 0.4 | 0.1 | 0.8 | 0.61 | 11.1 | 9.6 | 12.6 | 0.00 | 20.8 | 17.3 | 24.3 | 0.00 | 11.2 | 9.4 | 12.9 | 0.00 | 37.5 | 31.7 | 43.2 | 0.00 |
| Rat4 (5) | −1.0 | −1.8 | −0.1 | - | −3.2 | −3.5 | −2.8 | 0.00 | 8.2 | 6.7 | 9.7 | 0.00 | 12.6 | 9.9 | 15.2 | 0.00 | 9.2 | 6.9 | 11.6 | 0.00 | 27.3 | 22.2 | 32.4 | 0.00 |
| Rat5 (3) | 3.0 | 1.4 | 4.7 | - | 1.2 | 0.5 | 1.8 | 0.01 | 11.3 | 9.1 | 13.5 | 0.00 | 15.6 | 13.2 | 17.9 | 0.00 | 14.1 | 11.8 | 16.4 | 0.00 | 30.8 | 24.2 | 37.3 | 0.00 |
| dHPC | QW | NREM | AW | REM | REM-TONIC | REM-PHASIC | ||||||||||||||||||
| Animal | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | ||||||
| Rat1 (7) | 0.4 | −0.1 | 1.0 | - | −0.2 | −0.6 | 0.1 | 0.09 | 3.7 | 2.2 | 5.3 | 0.00 | 20.1 | 16.6 | 23.7 | 0.00 | 11.6 | 8.9 | 14.2 | 0.00 | 40.0 | 35.6 | 44.4 | 0.00 |
| Rat2 (7) | −0.8 | −1.4 | −0.2 | - | −4.1 | −4.5 | −3.7 | 0.00 | 5.3 | 3.1 | 7.5 | 0.00 | 19.5 | 15.0 | 24.0 | 0.00 | 10.3 | 7.3 | 13.4 | 0.00 | 44.1 | 38.3 | 50.0 | 0.00 |
| Rat3 (9) | −0.4 | −1.1 | 0.2 | - | 2.9 | 2.3 | 3.5 | 0.00 | 8.6 | 6.8 | 10.3 | 0.00 | 28.9 | 25.3 | 32.5 | 0.00 | 18.9 | 16.2 | 21.6 | 0.00 | 47.4 | 41.3 | 53.4 | 0.00 |
| Rat4 (5) | −0.7 | −1.6 | 0.2 | - | 1.1 | 0.6 | 1.5 | 0.00 | 6.6 | 5.5 | 7.6 | 0.00 | 29.2 | 25.1 | 33.3 | 0.00 | 23.1 | 19.7 | 26.5 | 0.00 | 55.4 | 48.2 | 62.5 | 0.00 |
| Rat5 (3) | 3.9 | 1.9 | 5.8 | - | 2.8 | 1.9 | 3.7 | 0.08 | 11.6 | 8.8 | 14.4 | 0.00 | 22.6 | 19.0 | 26.1 | 0.00 | 20.5 | 17.0 | 24.0 | 0.00 | 49.8 | 33.4 | 66.2 | 0.00 |
| dTHAL | QW | NREM | AW | REM | REM-TONIC | REM-PHASIC | ||||||||||||||||||
| Animal | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | ||||||
| Rat1 (7) | 0.1 | −0.2 | 0.5 | - | −0.5 | −0.9 | −0.2 | 0.26 | 7.4 | 6.3 | 8.4 | 0.00 | 21.1 | 17.9 | 24.3 | 0.00 | 13.4 | 10.6 | 16.2 | 0.00 | 37.9 | 33.9 | 41.9 | 0.00 |
| Rat2 (7) | −0.3 | −0.8 | 0.1 | - | −1.0 | −1.3 | −0.7 | 0.03 | 9.7 | 7.0 | 12.5 | 0.00 | 23.0 | 19.2 | 26.7 | 0.00 | 14.1 | 11.4 | 16.8 | 0.00 | 39.4 | 36.5 | 42.3 | 0.00 |
| Rat3 (9) | −0.9 | −2.0 | 0.1 | - | −2.0 | −2.6 | −1.4 | 0.03 | 6.0 | 3.1 | 8.8 | 0.00 | 24.1 | 19.8 | 28.4 | 0.00 | 14.1 | 12.2 | 16.1 | 0.00 | 47.8 | 39.2 | 56.4 | 0.00 |
| Rat4 (5) | −0.5 | −1.2 | 0.2 | - | −3.4 | −3.8 | −3.1 | 0.00 | 8.3 | 7.4 | 9.3 | 0.00 | 17.2 | 12.5 | 21.9 | 0.00 | 11.8 | 7.9 | 15.7 | 0.00 | 40.0 | 35.6 | 44.4 | 0.00 |
| Rat5 (3) | 2.7 | 1.0 | 4.5 | - | −2.8 | −3.7 | −1.9 | 0.00 | 10.3 | 7.1 | 13.5 | 0.00 | 18.3 | 14.9 | 21.7 | 0.00 | 16.5 | 12.9 | 20.1 | 0.00 | 35.0 | 20.8 | 49.2 | 0.00 |
| THAL | QW | NREM | AW | REM | REM-TONIC | REM-PHASIC | ||||||||||||||||||
| Animal | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | ||||||
| Rat1 (7) | 0.1 | −0.1 | 0.4 | - | −0.5 | −0.7 | −0.3 | 0.01 | 5.6 | 4.8 | 6.5 | 0.00 | 16.0 | 13.9 | 18.2 | 0.00 | 11.2 | 9.3 | 13.0 | 0.00 | 27.4 | 24.4 | 30.3 | 0.00 |
| Rat2 (7) | −0.1 | −0.5 | 0.2 | - | −2.0 | −2.3 | −1.7 | 0.00 | 6.0 | 4.9 | 7.2 | 0.00 | 14.2 | 11.6 | 16.9 | 0.00 | 10.2 | 7.4 | 13.0 | 0.00 | 25.4 | 22.7 | 28.0 | 0.00 |
| Rat3 (9) | 0.4 | 0.0 | 0.8 | - | −0.6 | −0.9 | −0.3 | 0.00 | 11.8 | 9.5 | 14.0 | 0.00 | 17.4 | 15.3 | 19.6 | 0.00 | 11.5 | 9.9 | 13.2 | 0.00 | 28.7 | 24.6 | 32.7 | 0.00 |
| Rat4 (5) | −0.6 | −1.1 | 0.0 | - | −3.1 | −3.2 | −2.9 | 0.00 | 4.0 | 3.4 | 4.7 | 0.00 | 12.8 | 10.8 | 14.9 | 0.00 | 9.7 | 7.9 | 11.6 | 0.00 | 26.6 | 23.7 | 29.6 | 0.00 |
| Rat5 (3) | 1.5 | 0.5 | 2.4 | - | −2.3 | −2.6 | −1.9 | 0.00 | 6.1 | 4.5 | 7.7 | 0.00 | 12.7 | 11.0 | 14.5 | 0.00 | 11.9 | 10.1 | 13.7 | 0.00 | 24.3 | 17.5 | 31.1 | 0.00 |
| WHOLE | QW | NREM | AW | REM | REM-TONIC | REM-PHASIC | ||||||||||||||||||
| Animal | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | Mean | IC_95% | p | ||||||
| Rat1 (7) | 0.1 | −0.2 | 0.3 | - | 1.0 | 0.7 | 1.2 | 0.00 | 4.7 | 3.6 | 5.9 | 0.00 | 14.4 | 12.2 | 16.6 | 0.00 | 9.0 | 7.5 | 10.5 | 0.00 | 26.8 | 24.5 | 29.1 | 0.00 |
| Rat2 (7) | −0.3 | −0.7 | 0.2 | - | −2.5 | −2.7 | −2.2 | 0.00 | 3.2 | 1.7 | 4.6 | 0.00 | 11.6 | 10.2 | 12.9 | 0.00 | 7.1 | 5.8 | 8.4 | 0.00 | 17.7 | 15.8 | 19.7 | 0.00 |
| Rat3 (9) | 0.5 | 0.1 | 0.9 | - | 0.7 | 0.4 | 1.0 | 0.17 | 9.4 | 8.0 | 10.8 | 0.00 | 21.1 | 18.2 | 24.1 | 0.00 | 12.7 | 10.9 | 14.5 | 0.00 | 36.0 | 31.4 | 40.7 | 0.00 |
| Rat4 (5) | −0.7 | −1.3 | 0.0 | - | −1.5 | −1.7 | −1.2 | 0.04 | 5.4 | 4.5 | 6.2 | 0.00 | 15.9 | 13.5 | 18.4 | 0.00 | 12.5 | 10.4 | 14.6 | 0.00 | 31.2 | 26.8 | 35.6 | 0.00 |
| Rat5 (3) | 2.2 | 1.0 | 3.4 | - | 0.2 | −0.3 | 0.8 | 0.00 | 8.5 | 6.8 | 10.1 | 0.00 | 14.5 | 12.5 | 16.5 | 0.00 | 13.3 | 11.4 | 15.3 | 0.00 | 28.4 | 22.2 | 34.5 | 0.00 |
The analysis is performed for five brain regions: cortex, dorsal Hippocampus (dHpc), dorsal Thalamus (dThal), Whole Thalamus (Thal), and Whole-brain (Whole). For each brain region, one row represents a single animal (the corresponding number of recordings is given between brackets) and a set of four columns corresponds to a single sleep state. For each sleep state, the left (bold) number is the mean CBV level, the second and third figures are the 95% confidence interval and the last value is the corresponding p-value for the observed sleep state to be drawn from the QW distribution. CBV levels are expressed in % of change relative to a baseline (3 first minutes of QW)