Prognostic analysis. Kaplan–Meier curves of overall survival at 5 years for patients with (A, C) colorectal cancer (GSE17536) and (B, D) lung adenocarcinoma (GSE31210) according to expression of (A, B) MTHFD2 and (C, D) TYMS. The horizontal axis shows follow-up time and the vertical axis shows survival rate. Solid line, low-expression group; dashed line, high-expression group.