Table 3.

Summary Table of the Classification of Antipsychotic Agents into Four Groups and Mode of Action Based on Prevalence Estimates of Acute Movement Disorders.

Prevalence of Movement Disorders	Medication	NbN Classification
High	Haloperidol Chlorpromazine L-sulpiride	D2 receptor antagonist D2 and 5-HT2 receptor antagonist D2 receptor antagonist
Moderate-to-high	Ziprasidone Aripiprazole Risperidone Amisulpride	D2 and 5-HT2 receptor antagonist D2 and 5-HT1A partial agonist and 5-HT2A receptor antagonist D2, 5HT2A and NE-alpha 2 receptor antagonist D2 receptor antagonist
Moderate-to-low	Olanzapine Paliperidone Asenapine	D2 and 5-HT2A receptor antagonist D2, 5HT2A and NE-alpha 2 receptor antagonist D2, 5HT2A and NE-alpha 2 receptor antagonist
Low	Clozapine Quetiapine	D2, 5HT2A and NE-alpha 2 receptor antagonist D2 and 5HT2A receptor antagonist – norepinephrine transporter inhibitor

The table indicates also their classification based on Principal Mode of Action, according to the neuroscience-based nomenclature (NbN).