Figure 1.

Experimental design. Human and mouse islets were transplanted under the kidney capsule of athymic nude mice (Tx). Ten to 14 days after transplantation, mice were intraperitoneally injected with five consecutive daily doses of either STZ (70 mg/kg body weight) or vehicle (citrate). Grafts were harvested on the last day of STZ injection to determine beta cell death, mass and vascular density or followed for seven additional days to assess the metabolic evolution.