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. 2018 Oct 4;27(11):1603–1612. doi: 10.1177/0963689718802754

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig 2. — Transplantation of hWJ-MSCs did not reduce microglial activation in the ischemic core area. hWJ-MSCs were pre-labeled with the fluorescent dye CM-Dil before grafting to stroke rats. Animals were perfused on day 5 after transplantation and stroke surgery. (A) Enhanced IBA1 immunoreactivity (green fluorescence) was found in the ischemic core in animals receiving vehicle or hWJ-MSCs. (A) Red CM-Dil fluorescence (+) cells were confined to the graft sites. No red fluorescence was found in animals receiving vehicle. (B) High-magnification confocal photomicrographs indicated that grafted cells (red fluorescence) were mainly in the microglia. Calibration = 10 μm.

CM-Dil: chloromethyl benzamide 1,1’-dioctadecyl-3,3,3’3’- tetramethylindocarbocyanine perchlorate; hWJ-MSC: Wharton’s jelly-derived mesenchymal stromal cell.