Table I.
Basic characteristics of the included studies.
| Study ID | Species | Sex | n (per group) | Sepsis model | Res administration and dose | Outcome | Notes | Refs. |
|---|---|---|---|---|---|---|---|---|
| Zhang et al | SD rats | Male | 15 | LPS (3 ml/kg, | 0.5% Res, (2 ml/kg, jugular injection, pre-LPS | 1. MDA | TNF-α from | 39 |
| (1995) | (214–265 g) | jugular injection) | and repeated 2 h after LPS administration). | 2. TNF-α | lung tissue. | |||
| The sample was obtained 5 h after LPS administration. | ||||||||
| Kolgazi et al | SD rats | Male | 7–8 | CLP | Res (3,5,4′-trans-trihydroxystilbene | 1. Serum TNF-α | MDA without obvious | 15 |
| (2006) | (200–250 g) | 30 mg/kg i.p. at 16 h after induction of sepsis). | 2. MDA | mean values. | ||||
| The samples were obtained 24 h after the sepsis induction. | ||||||||
| Larrosa et al | SD rats | Male | 12 | LPS | Res (3,5,4′-trans-trihydroxystilbene, | 1. MDA | TNF-α without obvious | 40 |
| (2011) | (150–200 g, | (20 mg/kg, i.p.) | 50 mg/kg p.o. the 3 days prior to LPS administration | 2. Serum TNF-α | mean values. | |||
| 7 weeks) | and 45 min later). The samples were obtained | |||||||
| 1 or 5 h after the sepsis induction. | ||||||||
| Yu et al | SD rats | Male | 30 | CLP | Res (3 ml/kg tail i.v. injection before CLP). | 1. IL-10 | 53 | |
| (2012) | (200–250 g, | The samples were obtained at different | ||||||
| 13–15 weeks) | times (0, 6, 12, 24 and 48 h). | |||||||
| Huang | C57/BL6 mice | Male | 8 | CLP | Res (20, 40 and 80 mg/kg 0.4 ml i.p. 2 h after CLP). | 1. Serum TNF-α | 46 | |
| (2015) | (15–21 g, 6 weeks) | The samples were obtained at different times (6, 12 and 24 h). | ||||||
| Wang | Wistar rats | Male | 6 | LPS | Res (30 mg/kg i.m. after LPS administration). | 1. MAP | Animals had albinism. | 47 |
| (2015) | (170–210 g) | (8 mg/kg, i.p.) | The samples were obtained 1 h after the sepsis induction. | |||||
| Wang et al | Mice | n/a | 4–6 | CLP | Res (3,5,4′-trans-trihydroxystilbene, 30 mg/kg i.p. | 1. MAP | Animals had obesity. | 43 |
| (2015) | (ob/ob−) | 18 h pre-sepsis). The samples were obtained 6 h post-surgery. | ||||||
| Yang | SD rats | Male or | 8 | CLP | Res (20–80 mg/kg i.p. administration | 1. Serum TNF-α | There was no specific | 44 |
| (2015) | female | starting 12 h after surgery). | 2. Serum IL-6 | collection time | ||||
| 3. MAP | for the samples. | |||||||
| Aydin et al | Wistar rats | 8 | CLP | Res (3,5,4′-trans-trihydroxystilbene, 100 mg/kg i.p. | 1. MDA | Serum TNF-α without | 41 | |
| (2016) | (200–300 g, | after induction of sepsis). At 24 h after | 2. Serum TNF-α | obvious mean values. | ||||
| 12 weeks) | the treatment the samples were obtained. | Animals had albinism. | ||||||
| Gan | SD rats | Male | 10 | CLP | Res (3 or 10 mg/kg i.p. administration 2 h after CLP). | 1. Serum TNF-α | 45 | |
| (2016) | (170–220 g) | The serum was obtained at different time-points; | 2. IL-6 | |||||
| 12 h after sepsis the sample was obtained. | 3. IL-10 | |||||||
| Lou | Wistar rats | Male | 8 | LPS | Res (50 mg/kg, femoral vein injection after blood | 1. MAP | Serum TNF-α | 42 |
| (2017) | (200–250 g) | (20 mg/kg, femoral | pressure was 30% lower than the basal value). | 2. Serum TNF-α | without obvious | |||
| vein injection) | The serum samples were obtained 4 h after | mean values | ||||||
| pressure of the abdominal aortic blood was stable. |
SD, Sprague-Dawley; LPS, lipopolysaccharide; CLP, cecum ligation and perforation; Res, resveratrol; MDA, malondialdehyde; MAP, mean arterial pressure; TNF-α, tumor necrosis factor-α; IL, interleukin; i.p., intraperitoneal; i.m., intramuscular; i.v., intranvenous; p.o., per os.