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Low sequence conservation between the proline-rich domain of human and mouse fXII. The primary sequence, including the N-terminal signal peptide of human fXII (hfXII) was aligned with that of mouse fXII (mfXII). The sequence between the conserved cysteines at positions 276 and 340 (highlighted in magenta) containing the proline-rich domain of hfXII is shown on the top. Note that this region is 18 residues shorter in mfXII (bottom). The sites cleaved by CpaA in hfXII are marked in green.
