TABLE 1.
MICs of β-lactam antibiotics against clostridial isolates
Antibiotic | MIC (µg/ml) |
||||||||
---|---|---|---|---|---|---|---|---|---|
C. difficile
ATCC 43255 |
C. difficile
630Δerm |
C. cochlearium
ATCC 17787 |
|||||||
cdd1 | cdd2 |
cdd2
intron |
Δcdd2 | Parental strain |
*cdd1 | *cdd2 | Pthl
cdd1 |
Pfdx
cdd1 |
|
Ampicillin | 4 | 4 | 1 | 1 | 0.03 | 0.25 | 0.25 | 32 | 16 |
Penicillin G | 4 | 4 | 1 | 1 | 0.015 | 0.25 | 0.25 | 32 | 16 |
Oxacillin | 8 | 64 | 64 | 64 | 0.25 | 2 | 1 | 64 | 16 |
Cephalothin | 16 | 32 | 32 | 32 | 0.12 | 0.5 | 0.25 | 32 | 16 |
Cefotaxime | 128 | 128 | 128 | 128 | 1 | 2 | 2 | 128 | 64 |
Ceftriaxone | 64 | 64 | 32 | 32 | 1 | 2 | 2 | 256 | 128 |
Cefoxitin | 128 | 128 | 128 | 128 | 0.25 | 0.25 | 0.25 | 0.5 | 0.5 |
Ceftazidime | 256 | 256 | 64 | 64 | 32 | 32 | 32 | 1,024 | 512 |
Cefepime | 64 | 64 | 32 | 32 | 16 | 16 | 16 | 256 | 128 |
Aztreonam | 2,048 | 2,048 | 2,048 | 2,048 | 512 | 512 | 512 | 512 | 256 |
Imipenem | 4 | 4 | 4 | 4 | 0.03 | 0.06 | 0.06 | 0.12 | 0.12 |
Meropenem | 2 | 4 | 4 | 4 | 0.007 | 0.015 | 0.015 | 0.03 | 0.03 |