FIG 5.

Phylogenetic analysis of APAZ domains. The circular phylogenetic tree of the five groups of APAZ domains. The phylogenetic tree was annotated as follows, from the inner to the outer circles: in the “protein type” circle the APAZ-containing proteins are colored according to their phylogenetic groups and domain compositions, where each type of protein structure is exemplified by the callouts with corresponding domain schemes; isolated APAZ domains in all groups are shown in light blue; the “operon” circle indicates whether the APAZ-containing protein is found in a pAgo coding operon; the “pAgo fusion” circle shows APAZ domains which are fused with short pAgo proteins; and the “kingdom” circle indicates the superkingdom to which the corresponding APAZ-containing protein belongs.