TABLE 1.
DG167 activity in laboratory and clinical strains of Mycobacterium speciesa
| Strain | Type | Resistance | DG167 MIC (µM) |
INH MIC (µM) |
|---|---|---|---|---|
| M. tuberculosis H37Rv | Laboratory | Susceptible | 0.39 | 0.4 |
| M. bovis BCG | Laboratory | Susceptible | 0.39 | 0.4 |
| M. tuberculosis DRM5 (12) | Laboratory | SQ109, DA5b | 0.39 | 0.4 |
| M. tuberculosis DRM8.3 (12) | Laboratory | SQ109, DA8b | 0.39 | 0.4 |
| M. tuberculosis mc24914 (32) | Laboratory | INH | 0.78 | 1.6 |
| M. tuberculosis DRM12c | Laboratory | INH | 0.39 | 0.4 |
| M. tuberculosis 210 | Clinical | Susceptible | 0.39 | 0.4 |
| M. tuberculosis TDR692 | Clinical | Susceptible | 0.39 | 0.2 |
| M. tuberculosis TDR31 | Clinical | INH, RIF, EMB, KAN, SM, CAP | 0.2 | >12 |
| M. tuberculosis TDR36 | Clinical | INH, RIF, EMB | 0.39 | >12 |
| M. tuberculosis TDR116 | Clinical | INH, EMB, PAS | 0.2 | >12 |
| M. smegmatis | Laboratory | Wild-type | >50 | >12 |
| M. abscessus | ATCC | Wild type | >50 | >12 |
| M. avium | ATCC | Wild type | >50 | >12 |
| M. fortuitum | ATCC | Wild type | >50 | >12 |
| M. marinum | ATCC | Wild type | >50 | >12 |
a
INH, isoniazid; RIF, rifampin; EMB, ethambutol; KAN, kanamycin; SM, streptomycin; CAP, capreomycin; PAS, para-aminosalicylic acid.
b
MmpL3 inhibitor (12).
c
M. tuberculosis H37Rv with KatG mutation (S315T) that confers INH resistance.