TABLE 2.
Genotypic and drug-resistance profile of DG167-resistant and KasA-overexpressing M. tuberculosis strains
| Strain | kasA SNPa | KasA mutationb | MIC (µM) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DG167 | INH | RIF | EMB | ETH | Moxi | BDQ | PA824 | SQ109 | |||
| M. tuberculosis H37Rv | None | 0.39 | 0.19 | 0.001 | 0.78 | 25 | 0.03 | 1 | 0.1 | 0.8 | |
| M. tuberculosis DRM167-16x3 | gTc-gCc | V123A | 1.56 | 0.38 | 0.001 | 1.56 | 25 | 0.03 | 0.5 | 0.1 | 0.8 |
| M. tuberculosis DRM167-8x6 | Atg-Ttg | M213L | 3.12 | 0.38 | 0.001 | 1.56 | 25 | 0.03 | 0.5 | 0.1 | 0.4 |
| M. tuberculosis DRM167-8x3 | aTc-aCc | I145T | 6.25 | 0.38 | 0.002 | 1.56 | 25 | 0.03 | 1 | 0.1 | 0.8 |
| M. tuberculosis DRM167-16x6 | aTt-aGt | I122S | 50 | 0.19 | 0.001 | 1.56 | 12.5 | 0.03 | 0.5 | 0.1 | 0.4 |
| M. tuberculosis DRM167-8x2 | Gcc-Acc | A119T | 50 | 0.38 | 0.001 | 1.56 | 12.5 | 0.03 | 0.5 | 0.1 | 0.8 |
| M. tuberculosis DRM167-32x11 | Ggc-Agc | G240S | 100 | 0.19 | 0.001 | 1.56 | 12.5 | 0.03 | 0.25 | 0.1 | 0.4 |
| M. tuberculosis DRM167-32x2 | Ccc-Acc | P206T | >100 | 0.19 | 0.001 | 1.56 | 12.5 | 0.03 | 0.12 | 0.1 | 0.4 |
a
Each capitalized letter in the codon indicates a nucleotide change.
b
Data indicate amino acid substitutions corresponding to kasA SNPs.