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. 2018 Nov 3;14(14):2037–2050. doi: 10.7150/ijbs.28435

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© Ivyspring International Publisher

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LIPOC ameliorates hepatic ischemia-reperfusion injury. (A) The establishment of the rat model for hepatic ischemia-reperfusion. Top left: anatomy of the left lobe, and the common running section of middle hepatic artery, portal vein, and bile duct; top right: noninvasive small blood vessels clamp was used to block the common running section to achieve a rat 70% hepatic ischemia model; bottom left: 70% liver warm ischemia for 1h; bottom right: reperfusion after 1h liver warm ischemia. (B) The scheme of treatment design for four tested groups: S, I/R, IPO and LIPOC. R represents reperfusion. (C) Pathological changes in liver sections under light microscope (x400 magnification). (D) Pathological changes in liver sections under electron microscope (x10,000 magnification).