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. 2018 Nov 3;14(14):2023–2036. doi: 10.7150/ijbs.28302

Figure 4.

Figure 4

Runx2 target genes are downregulated in AOB cells. (A) Runx2 target genes are downregulated in AOB cells. The relative mRNA levels of Runx2 target genes, including OSC, ALPL, SPP1, COL1A1, IBSP and MMP13, in HOB and AOB cells were determined by qRT-PCR. CUL4A was used as a control. *P<0.05. (B) The expression of Runx2 target genes was dependent on the CtBP2 level. The HOB-1, HOB-2, AOB-1 and AOB-2 cells were transfected with control-siRNA or CtBP2-siRNA, respectively. After 48 hours, the cells were subjected to RNA isolation, followed by measuring the expression of Runx2 target genes by qRT-PCR. CUL4A was used as a control. **P<0.001.