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. 2018 Nov 1;14(14):1960–1973. doi: 10.7150/ijbs.28048

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Exosomal MALAT1 promotes tumour angiogenesis, growth and implantation in vivo. (A) Effects of the exosomes derived from SKOV3.ip1 cells transfected with MALAT1-NC or MALAT1-KD on tumour progression in vivo. Representative images of tumour progression in mice from the 4 groups (the mice were injected with PBS, Exo/SKOV3.ip1-NC, Exo/SKOV3.ip1-KD1 or Exo/SKOV3.ip1-KD2) are shown. (B) The final tumour weight and number of tumour implants were determined after the mice were euthanized. * P<0.05. (C) Cell angiogenesis in vivo was assessed by CD31 immunostaining. Haematoxylin and eosin-stained images and immunohistochemistry analysis of CD31 protein levels in xenograft tumour tissues (bar: 100 µm).