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AFAP1-AS1 knockdown influences EMT-associated gene expression and the actin-cytokeratin signaling pathway. (A) qRT-PCR-measured mRNA expression of E-cadherin, vimentin, MMP9 and ZEB1 in siRNA2-transfected HT-29 cells. (B) The protein expression of E-cadherin, Vimentin, MMP9, ZEB1, β-catenin and ZO-1 were detected by Western blotting. (C) Western blotting analysis showed that CTTN, RHOA and RAB1B were elevated while MPRIP decreased after silencing AFAP1-AS1.
