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. 2018 Dec 10;9(24):4762–4773. doi: 10.7150/jca.25138

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Cooperative effect of KPT-330 and dasatinib on cell signaling. A. Western blot analysis of pancreatic cancer cells (MiaPaCa2, Panc1) treated with KPT-330 (10 μM, 36h). Changes in expression of XPO1 as well as proteins related to cell proliferation and apoptosis (BIM, BAX, BCL2, BCL-XL, MYC, SURVIVIN). B. MiaPaCa2 pancreatic cancer cell line was treated with dasatinib (200 nM) and/or KPT-330 (10 μM) for 16 h. Phosphorylation levels of SRC, FAK, AKT, and ERK1/2 were detected by Western blot analysis. Actin was used as loading control. pSRC, phosphorylated SRC; pFAK, phosphorylated FAK; pAKT, phosphorylated AKT; pERK1/2, phosphorylated ERK.