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. 2018 Dec 10;9(24):4762–4773. doi: 10.7150/jca.25138

Figure 6.

Figure 6

KPT-330 was synergistic with dasatinib in the inhibition of pancreatic tumor growth in vivo. MiaPaCa2 cells were injected subcutaneously in immunodeficient mice. After the tumors became palpable, mice were treated with KPT-330 (10 mg/kg by oral gavage), dasatinib (10 mg/kg intraperitoneally), combination of KPT-330 and dasatinib, or diluent control, as described in Materials and Methods. A. At the end of the experiments, tumors were weighed. Student t-test was used to compare the difference among the tumors. ns: nonsignificant; *: p < 0.05; **: p < 0.01. B. Immunohistochemical staining with Ki-67 and phosphorylated ERK (pERK) on xenografts. Image magnification, 20x; scale bar, 100 μm. Representative slides are shown.