Table 3.

Anti-tumor activity of XPO1 inhibitors against pancreatic cancer cells (IC50*, M)

	KPT-185	KPT-276	KPT-330
SU8686	3.5 x 10-6	6.7 x 10-6	9.2 x 10-7
MiaPaCa2	2.4 x 10-6	1.1 x 10-5	7.2 x 10-7
Panc1	1.1 x 10-6	2.9 x 10-6	1.1 x 10-6
BxPc3	9.6 x 10-6	1.6 x 10-5	1.2 x 10-5
Panc0203	R	2.2 x 10-5	5.6 x 10-6
Panc1005	1.5 x 10-6	1.3 x 10-5	1.3 x 10-6
Panc0813	1.7 x 10-6	2.3 x 10-6	4.1 x 10-7
AsPc1	2.9 x 10-5	R	R

Cell lines were cultured with three XPO1 inhibitors for 72 and cell viability was measured by MTT assay. *IC50s were extrapolated from MTT data using Graphpad Prism software as described in Materials and Methods. R: resistant.