Table 2.
Distribution frequency of HMGB1 genotypes in 862 controls and 431 UCC patients.
| Variable | Controls (N= 862) n(%) | Patients(N=431) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs1412125 | ||||
| TT | 448 (52.0%) | 231 (53.6%) | 1.00 | 1.00 |
| TC | 336 (39.0%) | 175 (40.6%) | 1.010 (0.793-1.287) | 1.015 (0.792-1.301) |
| CC | 78 (9.0%) | 25 (5.8%) | 0.622 (0.386-1.002) | 0.555 (0.341-0.902)* |
| TC+CC | 414 (48.0%) | 200 (46.4%) | 0.937 (0.743-1.181) | 0.922 (0.727-1.169) |
| rs1360485 | ||||
| TT | 474 (55.0%) | 255 (59.2%) | 1.00 | 1.00 |
| TC | 327 (37.9%) | 154 (35.7%) | 0.875 (0.685-1.118) | 0.874 (0.680-1.123) |
| CC | 61 (7.1%) | 22 (5.1%) | 0.670 (0.402-1.117) | 0.646 (0.384-1.088) |
| TT+CC | 388 (45.0%) | 176 (40.8%) | 0.843 (0.667-1.066) | 0.837 (0.659-1.064) |
| rs1045411 | ||||
| CC | 503 (58.4%) | 283 (65.7%) | 1.00 | 1.00 |
| CT | 304 (35.3%) | 127 (29.5%) | 0.743 (0.576-0.956)* | 0.732 (0.565-0.949)* |
| TT | 55 (6.4%) | 21 (4.8%) | 0.679 (0.402-1.145) | 0.668 (0.392-1.139) |
| CT+TT | 359 (41.6%) | 148 (34.3%) | 0.733 (0.576-0.932)* | 0.722 (0.565-0.924)* |
| rs2249825 | ||||
| CC | 606 (70.3%) | 299 (69.4%) | 1.00 | 1.00 |
| CG | 233 (27.0%) | 121 (28.1%) | 1.053 (0.812-1.365) | 1.018 (0.780-1.327) |
| GG | 23 (2.7%) | 11 (2.5%) | 0.969 (0.466-2.015) | 0.871 (0.414-1.834) |
| CG+GG | 256 (29.7%) | 132 (30.6%) | 1.045 (0.813-1.344) | 1.004 (0.776-1.299) |
The odds ratio (OR) with their 95% confidence intervals were estimated by logistic regression models. The adjusted odds ratio (AOR) with their 95% confidence intervals were estimated by multiple logistic regression models after controlling for age, gender and tobacco consumption. Note: * and Bold text indicated a significant association with p value <0.05.