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. 2018 Oct 20;15(14):1582–1590. doi: 10.7150/ijms.28452

Figure 2.

Figure 2

Histological findings. (a) Cell penetration was observed at the entrance of the TCP holes. (b) Fibrous connective tissue was observed filling the TCP holes up to the center, but no hard tissue formation was observed. (c) Chondrogenesis was observed filling the TCP holes (white arrowheads). Inset: Toluidine blue staining positive images. (d) Invasion and proliferation of fibrous connective tissue and cartilage formation (white arrowheads) were observed in about one-third of the area from the entrance of the TCP holes. Inset: Toluidine blue staining positive images. (e) Cell infiltration was observed up to the center of the TCP holes, and bone formation was observed on the inner walls (arrowheads). (f) Formation of bone and bone marrow-like tissue (asterisks) was found in the TCP holes. (g) Infiltration of fibrous connective tissue and cartilage formation (white arrowheads) were observed in about one-third of the area from the entrance of the TCP holes. Inset: Toluidine blue staining positive images. (h) Bone formation (arrowheads) was found around the thick blood vessels. (i) Numerous newly cancellous bone tissues were observed (arrowheads).