Overall survival and disease-free survival rates of ICC patients with differential CK expression were estimated by the Kaplan-Meier method and the log-rank test. The overall survival rates in ICC patients with IRS=6 CK7 expression was greater than the patients with IRS<6 CK7 expression (50.0 months vs. 20.0 months, p =0.628)(A); with normal CK19 expression was less than the patients with decreased CK19 expression (4.0 months vs. 33.0 months, p =0.743)(B); with normal CK8 expression was less than the patients with decreased CK8 expression (33.0 months vs. > 50%, p =0.261)(C); with normal CK18 expression was greater than the patients with decreased CK18 expression (43.0 months vs. 19.0 months, p =0.953)(D). The disease-free survival rates in ICC patients with IRS=6 CK7 expression was less than the patients with IRS<6 CK7 expression (14.0 months vs. 19.0 months, p =0.848)(E); with normal CK19 expression was less than the patients with decreased CK19 expression (2.0 months vs. 18.0 months, p =0.854)(F); with normal CK8 expression was less than the patients with decreased CK8 expression (10.0 months vs. 19.0 months, p =0.146)(G); with normal CK18 expression was less than the patients with decreased CK18 expression (18.0 months vs. 19.0 months, p =0.789)(H).