Table 1.

Phenotypical and molecular findings in the high fat diet model of NAFLD. This table summarized findings for various in vivo models demonstrating the diet induced molecular alterations of hepatic and adipogenic markers in the pathogenesis of NAFLD.

Reference		Finding
12	Species: Mouse Strain: C57BL/6 Diet: HFD for 24 weeks	Induced expression of adipogenic genes: aP2 and PPARγ Increased cytoplasmic aP2 and albumin protein Reduction in membrane bound E-cadherin and albumin expression Impaired adiponectin activity: upregulation of CD36, decreased hepatic adiponectin, decreased adiponectin receptor-2
34	Species: Mouse Strain: C57Bl/6Ncrj Diet: HFD for 2-12 weeks	Lipid accumulation at 2 weeks Fatty liver phenotype at 12 weeks Upregulation of genes of lipid metabolism: PPARγ and CD36 Suppression of CREBP
89	Species: Mouse Strain: C57BL/6 Diet: HFD for 15 weeks	Induced expression of following genes: hepatic fat accumulation: PPARγ, CD36, FABP4 macrophage markers: F4/80, CD68 inflammatory proteins: TNFα, MCP-1 and CCR2
90	Species: Mouse Strain: Fat aussie foz/foz Diet: HFD for 300 days	Severe steatohepatitis with hepatocyte ballooning, inflammation, and fibrosis Increased expression of the lipogenic gene SREBP1c Decreased expression of mitochondrial UCP2 Decreased hepatic lipid disposal gene expression of PPARα Increased adipogenic gene expression of aP2
91	Species: Rat Strain: Sprague—Dawley Diet: HFD with 5% cellulose for 7 weeks	Induction of lipogenic genes PPARγ, SREBP1c, FAS and FABP4

Abbreviations: aP2 - adipocyte protein 2; PPARγ - peroxisome proliferator activated receptor gamma; CREBP - cAMP response element binding protein; FABP4 - fatty acid binding protein 2; TNFα - tumor necrosis factor alpha; MCP-1 - monocyte chemoattractant protein 1; CCR2 - C-C chemokine receptor type 2; SREBP-1c - sterol regulatory element binding protein 1c; UCP2 - uncoupling protein 2; PPARα - peroxisome proliferator activated receptor alpha; FAS - fatty acid synthase.