Table 2.

Diagnostic and predictive performance of individual microRNA and Indice on BRONJ progression (second part)

miRNA	Cutoff value	AUC (95% CI)	p value	Designed Sensitivity# (%)	Specificity (%)	Accuracy (%)	True positive	True negative	False positive	False negative
Control Vs BRONJ-1w
miR-21	0.21	0.61 (0.44-0.79)	0.224	80.00	30.00	55.00	16	6	14	4
miR-23a	0.32	0.64 (0.48-0.82)	0.099	80.00	40.00	60.00	16	8	12	4
miR-145	0.80	0.65 (0.47-0.83)	0.108	80.00	50.00	65.00	16	10	10	4
Indice	-0.37	0.65 (0.47-0.84)	0.048	80.00	55.00	67.50	16	11	9	4
Control Vs BRONJ-4w
miR-21	0.12	0.73 (0.55-0.91)	0.013	80.00	25.00	52.50	16	5	15	4
miR-23a	0.30	0.71 (0.55-0.87)	0.024	80.00	40.00	60.00	16	8	12	4
miR-145	0.53	0.67 (0.50-0.85)	0.049	80.00	55.00	67.50	16	11	9	4
Indice	-0.25	0.75 (0.60-0.91)	0.006	80.00	55.00	67.50	16	11	9	4
Control Vs BRONJ-8w
miR-21	0.24	0.74 (0.57-0.90)	0.011	80.00	40.00	60.00	16	8	12	4
miR-23a	0.37	0.73 (0.57-0.89)	0.010	80.00	40.00	60.00	16	8	12	4
miR-145	0.49	0.71 (0.54-0.88)	0.021	80.00	65.00	72.50	16	13	7	4
Indice	-0.09	0.85 (0.73-0.97)	<0.001	80.00	70.00	75.00	16	14	6	4

Note: Designed sensitivity^#: the performance was considered by defining a cutoff value corresponding to fixing the sensitivity to 80.00%.