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. 2018 Nov 13;8(21):5945–5959. doi: 10.7150/thno.28068

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Benzoic acid produced by the gut microbiota inhibited D-amino acid oxidase in the brain. (A) The activity of carboxylesterase in the liver and gut microbiota of normal mice and in the liver of antibiotic-treated mice. (B) The percentage of the generated benzoic acid (BA) in the liver homogenate and the gut microbiota of mice after incubation with albiflorin (Alb, 250 μg/mL) at 37 °C for 1 h. (C) The percentage of the remaining D-serine in pure D-amino acid oxidase (DAAO) system in vitro. (D) The activity of D-amino acid oxidase in mice brain homogenate after treatment with benzoic acid (5 μg/mL, 10 μg/mL) and albiflorin (10 μg/mL). NS: no significance.