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. 2018 Nov 13;8(21):5986–5994. doi: 10.7150/thno.26650

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Exosomal EphA2 confers GEM resistance. (A) Western blot and (B) GAPDH-normalized EphA2 levels in PANC-1 cells transduced with lentiviruses expressing EphA2_shRNA_1, EphA2_shRNA_2, or Ctrl_shRNA. (C) Viability of PANC-1^Ctrl_shRNA and PANC-1^EphA2- (EphA2_shRNA_1 transduced) cells after 72h GEM treatment, normalized to untreated cell viability. (D-E) GEM cytotoxicity (100nM for 72 h) in (D) MIA PaCa-2 and (E) BxPC-3 cells after exposure to 20 µg/mL EXO_PANC-1 or EXO_PANC-1^EphaA2- or recombinant EphA2 (0.5 µg/mL). Data represent mean±SD; Western: n=3; MTT assay: n=6; *p<0.05, **p<0.01, ***p<0.001.