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Schematic illustration of the NTR-responsive NIR II fluorescence/PA probe for visualizing tumors and inducing an NTR-triggered PTT effect. (A) Catalyzed mechanism of IR1048-MZ activated by NTR. Frontier molecular diagram profiles of IR1048-MZ and IR1048-MZH. (B) The NIR II/PA/PTT of IR1048-MZ is quenched in the vessels and normal tissues. In contrast, the NIR II/PA/PTT of IR1048-MZ is activated by NTR when meeting cancer cells and hypoxic tumors.
