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. 2018 Nov 12;8(21):5890–5902. doi: 10.7150/thno.27667

Figure 2.

Figure 2

BPI-9016M inhibits downstream signals of c-Met, colony formation and cell cycle. (A) C-Met, ERK, AKT, and phosphorylation of these protein were detected by Western blotting in the PDX tissues following vehicle or BPI-9016M treatment. (B) C-Met, ERK, AKT, and phosphorylation of these protein were detected by Western blotting in the A549 and H1299 cells after treatment with serial doses of BPI-9016M treatment. (C-D) Colony formation rate (C) and colony size (D) of A549 and H1299 cells treated with BPI-9016M. (E) Cell cycle distribution of A549 and H1299 cells treated with BPI-9016M. (F) Cyclin D1 and CDK4 were analyzed by Western blotting of cells after treatment with BPI-9016M. (C- E) * p<0.05, ** p<0.001, *** p<0.0001.