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. 2018 Nov 12;8(21):5903–5914. doi: 10.7150/thno.27679

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¹²⁴I-A11 cMb-Cy5.5 PET/fluorescence shows specific targeting of PC3-PSCA subcutaneous tumors. (A) ¹²⁴I-A11 cMb-Cy5.5 PET/CT scans at 22 h post-injection (nude mice, n=5) show specific uptake in subcutaneous PC3-PSCA (+, right shoulder) tumors and no nonspecific uptake in PC3 tumors (PSCA-, left shoulder). Images are represented as whole-body MIPs. (B) Ex vivo biodistribution (22 h p.i.) confirms higher %ID/g uptake in PC3-PSCA tumors than PC3 tumors. (C) Ex vivo fluorescence (Cy5.5) imaging revealed strong fluorescence signal in PC3-PSCA tumors and excellent contrast to PC3 control tumors. B: bladder; R.E.: radiance efficiency ; St: stomach; Th: thyroid.

Inline graphic — ¹²⁴I-A11 cMb-Cy5.5 PET/fluorescence shows specific targeting of PC3-PSCA subcutaneous tumors. (A) ¹²⁴I-A11 cMb-Cy5.5 PET/CT scans at 22 h post-injection (nude mice, n=5) show specific uptake in subcutaneous PC3-PSCA (+, right shoulder) tumors and no nonspecific uptake in PC3 tumors (PSCA-, left shoulder). Images are represented as whole-body MIPs. (B) Ex vivo biodistribution (22 h p.i.) confirms higher %ID/g uptake in PC3-PSCA tumors than PC3 tumors. (C) Ex vivo fluorescence (Cy5.5) imaging revealed strong fluorescence signal in PC3-PSCA tumors and excellent contrast to PC3 control tumors. B: bladder; R.E.: radiance efficiency ; St: stomach; Th: thyroid.