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. 2018 Dec 19;8:17970. doi: 10.1038/s41598-018-36231-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the mRNA expression and significantly differentially expressed mRNAs between the parental and docetaxel-resistant cell groups. (A) Volcano figure showing the significantly differentially expressed genes in the MDA-RES and MCF7-RES cells in comparison to their parental cells. The blue dots represent mRNAs with |Log2FC| > 1, FDR < 0.1. (B) Venn diagrams of the significantly up-regulated or down-regulated mRNAs in both of the cells. (C) Complete-linkage clustering with the 124 consistent SDE mRNAs in the 12 samples. D. KEGG pathway enrichment and GO analysis for the consistent SDE genes. Left panel: GO functional classification of the consistent SDE genes. Red, green, and blue represent the three classes of the GO term. The top 10 enriched GO terms are shown in each class. Right panel: Scatter plot for the KEGG enrichment of the consistent SDE genes. RichFactor is the ratio of the consistent SDE genes annotated in a pathway to all the genes in this pathway. The Q value is the corrected p-value. The top 14 pathways with a Q value < 0.05 are shown in the figure.