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. 2018 Dec 19;8:17970. doi: 10.1038/s41598-018-36231-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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lncRNA-mRNA co-expression network construction and docetaxel-resistant module detection using the consistent SDE mRNAs and lncRNAs. (A) A total of 72 SDE lncRNAs and 124 SDE mRNAs were subjected to the WGCNA analysis. Using the hierarchical clustering method, 4 groups of co-expressed genes, termed ‘modules’, were identified. (B) The 4 modules were related to the docetaxel-resistant status. The correlation coefficients representing the module-trait relationships are indicated in the center of the modules, and the corresponding P-values are in the brackets. (C) The hub genes in the Turquoise and Gray modules were visualized by Cytoscape. Pathway enrichment was performed with the hub genes in the two modules. a. The connections of the 59 hub genes in the Turquoise module. The white nodes represent the hub genes, and the red lines indicate the connections to ABCB1. b. The connections of the 29 hub genes in the Gray module. The white nodes represent the hub genes, and the red lines indicate the connections to NONHSAG041250.2 (EPB41L4A-AS2).