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. 2018 Dec 11;9(6):e00955-18. doi: 10.1128/mBio.00955-18

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FIG 4 — Identification of V3 loop residues that stabilize the Env trimer via interaction with the V2 loop tyrosines. Neutralization sensitivities of single V3 loop mutants (N300A, N302A, R304A, and K305A mutants) of HIV-1 BaL compared to those of the wild-type virus. A selected panel of inhibitors were tested to assess the neutralization profile of V3 loop mutants, including sCD4, weakly neutralizing antibodies (412d, 447-52D), and broadly neutralizing antibodies (PG9, 2G12). The neutralization tests were performed using the TZM-bl assay.