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. 2018 Dec 11;9(6):e00955-18. doi: 10.1128/mBio.00955-18

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FIG 5 — Sera from HIV-1-infected patients contain high titers of neutralizing antibodies against V2 loop tyrosine mutants. (A) Neutralization sensitivities of HIV-1 BaL (tier 1b) V2 loop tyrosine mutants to pooled sera from chronically HIV-1-infected individuals (HIV-Ig) or a representative HIV-1-seropositive patient serum (N25). (B) Half-maximal neutralization titers (IC₅₀s) against HIV-1 BaL wild-type virus versus the Y173A Y177A double-alanine mutant in a panel of sera with different neutralization potencies (potent neutralizers, left panel; weak neutralizers, right panel). The fold increases in neutralization (IC₅₀ ratio) between the wild-type and the Y173A Y177A mutant are shown in the right column. The asterisks indicate the data columns that were compared by unpaired t test: *, neutralization titers against WT virus; **, neutralization titers against Y173A Y177A mutated virus. The neutralization tests were performed using the TZM-bl assay.