Table 1.
Comparison of Demographics and Computed Tomography Characteristics of Participants
| Stratum 1 (n = 75) | Stratum 2 (n = 75) | Stratum 3 (n = 75) | Stratum 4 (n = 75) | |
|---|---|---|---|---|
| Age (years) | 54.3 (9.5) | 59.8 (9.3) | 64.8 (8.5) | 64.8 (6.7) |
| Sex, Male (%) | 32 (42.7%) | 56 (74.7%) | 64 (85.3%) | 57 (76.0%) |
| Race, White (%) | 49 (65.3%) | 50 (66.7%) | 66 (88.0%) | 63 (84.0%) |
| BMI (kg/m2) | 28.4 (5.5) | 28.3 (4.6) | 27.8 (4.0) | 26.6 (4.8) |
| Smoking Pack-years | 0 (0) | 40.6 (17.5) | 49.8 (22.4) | 56.5 (21.9) |
| Hypertension (%) | 24 (32%) | 31 (41.3%) | 42 (56%) | 40 (53.3%) |
| Diabetes mellitus (%) | 4 (5.3%) | 10 (13.3%) | 19 (25.3%) | 10 (13.3%) |
| FEV1 (L) | 3.06 (0.69) | 3.24 (0.71) | 2.79 (0.62) | 1.23 (0.26) |
| FEV1% pred | 102.2 (12.1) | 101.1 (11.2) | 87.0 (15.8) | 39.8 (8.1) |
| FVC (L) | 3.76 (0.90) | 4.18 (0.92) | 4.46 (0.90) | 3.20 (0.76) |
| FVC %pred | 97.8 (11.1) | 99.9 (11.1) | 104.9 (15.6) | 77.5 (14.4) |
| FEV1/FVC | 0.82 (0.05) | 0.78 (0.05) | 0.62 (0.06) | 0.39 (0.09) |
| Percentage Emphysema | 1.6 (1.7) | 2.0 (1.8) | 5.2 (5.1) | 17.6 (11.4) |
| Pi10 | 3.67 (0.09) | 3.68 (0.07) | 3.70 (0.08) | 3.74 (0.08) |
| CAC | 2.0 (2.8) | 3.6 (3.5) | 6.5 (4.2) | 6.5 (4.0) |
| Statinsa (%) | 19 (25.3%) | 25 (33.3%) | 45 (60.0%) | 32 (42.7%) |
| Centrilobular Emphysema (%) | ||||
| Mild (yes/no) (%) | 3 (4%) | 13 (17.3%) | 20 (26.7%) | 8 (10.7%) |
| Moderate (yes/no) (%) | 0 (0%) | 4 (5.3%) | 21 (28%) | 22 (29.3%) |
| Advanced/Confluent (yes/no) (%) | 0 (0%) | 4 (5.3%) | 17 (22.7%) | 42 (56%) |
| Substantial Paraseptal Emphysema (yes/no) (%) | 0 (0%) | 10 (13.3.%) | 16 (21.3%) | 13 (17.3%) |
| Definite Bronchial Wall Thickening (yes/no) (%) | 0 (0%) | 5 (6.7%) | 17 (22.7%) | 29 (38.7%) |
All values shown as mean (standard deviation) unless otherwise stated
FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity, CAC Coronary artery calcification, Pi10 Square root of the wall area of a theoretical circular cross section of an airway with 10 mm lumenal perimeter
Stratum 1 = Lifetime non-smokers
Stratum 2 = Smokers without airflow obstruction. FEV1/FVC ≥0.70
Stratum 3 = Mild to moderate airflow obstruction. FEV1/FVC < 0.70, FEV1 ≥ 50%predicted
Stratum 4 = Severe to very severe airflow obstruction. FEV1/FVC < 0.70, FEV1 < 50%predicted
aMedication data displayed for usage in the three months prior to enrollment