Table 1.
Variable | n | AZIN1 RNA editing | P value | ADAR1 expression | P value | ||
---|---|---|---|---|---|---|---|
High (n = 56) | Low (n = 84) | High (n = 78) | Low (n = 62) | ||||
Gender | |||||||
Male | 110 | 44 | 66 | 1 | 62 | 48 | 0.77 |
Female | 30 | 12 | 18 | 16 | 14 | ||
Age (year) | |||||||
69≥a | 72 | 31 | 41 | 0.45 | 42 | 30 | 0.52 |
>69 | 68 | 25 | 43 | 36 | 32 | ||
Histological type | |||||||
Intestinal type | 69 | 29 | 40 | 0.63 | 41 | 28 | 0.39 |
Diffuse type | 71 | 27 | 44 | 37 | 34 | ||
Pathological T category | |||||||
pT1/2 | 50 | 14 | 36 | 0.031* | 24 | 26 | 0.17 |
pT3/4 | 90 | 42 | 48 | 54 | 36 | ||
Vessel invasion | |||||||
Present | 111 | 43 | 68 | 0.55 | 62 | 49 | 0.95 |
Absent | 29 | 13 | 16 | 16 | 13 | ||
Lymphovascular invasion | |||||||
Present | 128 | 52 | 76 | 0.62 | 74 | 54 | 0.1 |
Absent | 12 | 4 | 8 | 4 | 8 | ||
Lymph node metastasis | |||||||
N0 | 43 | 11 | 32 | 0.021* | 18 | 25 | 0.029* |
N1 | 97 | 45 | 52 | 60 | 37 | ||
Peritoneal metastasis | |||||||
P0 | 117 | 43 | 74 | 0.08 | 61 | 56 | 0.06 |
P1 | 23 | 13 | 10 | 17 | 6 | ||
Distant metastasis | |||||||
M0 | 101 | 39 | 62 | 0.59 | 49 | 52 | 0.006* |
M1 | 39 | 17 | 22 | 29 | 10 | ||
UICC TNM classification | |||||||
Stage I | 23 | 5 | 18 | 0.028* | 11 | 12 | 0.004* |
Stage II | 39 | 12 | 27 | 15 | 24 | ||
Stage III | 39 | 22 | 17 | 23 | 16 | ||
Stage IV | 39 | 17 | 22 | 29 | 10 |
* P < 0.05
aThe median age at surgery is 69 years in this cohort