Fig. 3.

Genetic environment of novel ICE harbouring bla_DIM-1 (a), bla_IMP-1 (b and c) and a double copy of bla_KPC-2 (d). Arrows indicate the direction of transcription for genes. The dashed part of the arrow indicates which end is missing, for other features the missing end is shown by a zig-zag line. Gene cassettes are shown by pale blue boxes, the conserved sequences (5′ and 3’-CS) of integrons as orange boxes and insertion sequences as white block arrows labelled with the IS number/name, with the pointed end indicating the inverted right repeat (IRR). Gaps > 50 bp are indicated by dashed red lines and the length in bp given. Unit transposons are shown as boxes of different colours and their IRs are shown as flags, with the flat side at the outer boundary of the transposon. DRs are shown as ‘lollipops’ of the same colour