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. 2018 Nov 29;8(22):6111–6120. doi: 10.7150/thno.29435

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Dynamics of the S1P-induced responses in the awake hypoxic mouse brain. (a) Time-lapse PAM of the hemodynamic changes before (normoxia and hypoxia) and after the injection of SLM6031434 (0.5, 1, 1.5, and 2 hours). Time courses of (b) C_Hb, (c) arterial sO₂, (d) venous sO₂, (e) OEF, (f) average vessel diameter, (g) average blood flow speed, (h) regional CBF, and (i) regional CMRO₂. Scale bar, 500 µm. Data are shown as Mean ± SD. *, p<0.05.