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. 2018 Nov 29;8(22):6322–6349. doi: 10.7150/thno.27828

Figure 7.

Figure 7

MR analysis of human cervical tumor-bearing mice using UCS-Gd-DOX. (A) 2D-slice images of tumor (black circles), where the color bar indicates the MR signal intensity. Only the image pixels with intensity values between ±2 standard deviations (STD) of the ROI signal were kept to avoid image artifacts. (B) SNR for each slice in (A) at time points: pre-scan (-206 min), 30 min, 82 min, 151 min, 203 min, 255 min, and 487 min. (C) Contrast-to-noise ratio (CNR) of tumor, liver, kidney, CuSO4, and noise area before and after injection. Here CNR % = (SNRpostinjection - SNRpreinjection) / SNRpreinjection ×100%. Error bars represent mean ± standard deviation (n = 3 mice). (D) T1-weighted MR images acquired by "spin-echo multiple slices" (SEMS) and then processed by "maximum intensity projection". Repetition time (TR) = 200 ms, echo time (TE) = 10 ms, field of view (FOV) = 64×32 mm2, matrix size = 256×128, slice thickness = 0.5 mm. The ROIs of tumor, liver, kidney, and CuSO4 reference are indicated by red, blue, green, and cyan shades, respectively.