Scheme 1.

Schematic illustration of QDs@TA‐PEG/DOX for enhanced chemotherapy by simultaneous ATP‐responsive chemodrug release and cancer cell sensitization. The nanoagent was constructed via one‐step assembly of tannic acid, QDs, and DOX mediated by metal–phenolic coordination, which displayed ATP‐activated disassembly due to the strong metal–triphosphate coordination. Upon entering cancer cells, the nanoagent enabled ATP‐responsive drug release and cellular ATP depletion, resulting in the increased cell chemosensitivity and enhanced therapeutic efficacy without causing side effects to normal cells.