Table 4.
Mann–Whitney U test Pairwise Across Groups and Listed Metabolites
| Mann–Whitney U Test for LGG, HGG, and MET Across Tissue Types and Listed Metabolites | Mann–Whitney U Values with P-Value | tLip/tCho | Ins/tCho | tCho/tCr | NAA/tCho | tCr/tCho |
|---|---|---|---|---|---|---|
| LGG vs. HGG for EDEMA | Mann–Whitney U | 29.000 | 7.000 | 25.000 | 25.000 | 24.000 |
| HGG n = 12, LGG n = 5, | P-value < | .916 | .020a | .598 | .598 | .527 |
| HGG vs. MET for EDEMA | Mann–Whitney U | 53.000 | 39.000 | 49.000 | 46.000 | 19.000 |
| HGG n = 12, MET n = 9 | P-value < | .943 | .680b | .722 | .570 | .013 |
| LGG vs. MET for EDEMA | Mann–Whitney U | 22.000 | 8.000 | 21.000 | 11.000 | 10.000 |
| LGG n = 5, MET n = 9 | P-value < | .947 | .079c | .841 | .125 | .096 |
| HGG vs. LGG for Contrast-Enhancement | Mann–Whitney U | 8.000 | 8.000 | 25.000 | 41.000 | 14.000 |
| HGG n = 12, LGG n = 7 | P-value < | .004 | .004 | .151 | .933 | .018 |
| HGG vs. MET for Contrast-Enhancement | Mann–Whitney U | 48.000 | 29.000 | 47.000 | 51.500 | 38.000 |
| HGG n = 12, MET n = 10 | P-value < | .429 | .076d | .391 | .575 | .147 |
| LGG vs. MET for Contrast-Enhancement | Mann–Whitney U | 0.000 | 1.000 | 26.000 | 30.000 | 21.000 |
| LGG n = 7, MET n = 10 | P-value < | .001 | .001e | .380 | .626 | .172 |
| HGG vs. MET for Cystic/Necrosis | Mann–Whitney U | 12.000 | 7.000 | 14.000 | 6.000 | 17.000 |
| HGG n = 9, MET n = 4 | P-value < | .355 | .229f | .537 | .064 | .877 |
| HGG vs MET for Ipsilateral NAWM | Mann–Whitney U | 32.000 | 29.000 | 22.000 | 19.000 | 34.000 |
| HGG n = 13, MET n = 9 | P-value < | .077 | .049 | .015 | .017g | .192g |
| HGG vs. LGG for Ipsilateral NAWM | Mann–Whitney U | 45.000 | 37.000 | 36.500 | 50.000 | 41.000 |
| HGG n = 13, LGG n = 8 | P-value < | .612 | .277 | .261 | .885 | .426 |
| LGG vs. MET for Ipsilateral NAWM | Mann–Whitney U | 20.000 | 26.000 | 12.000 | 12.000 | 25.000 |
| LGG n = 8, MET n = 9 | P-value < | .124 | .336 | .021 | .036h | .462h |
| HGG vs. MET for Contralateral NAWM | Mann–Whitney U | 45.000 | 36.000 | 51.000 | 36.000 | 41.000 |
| HGG n = 13, MET n = 8 | P-value < | .817i | .355i | .942 | .247 | .426 |
| HGG vs. LGG for Contralateral NAWM | Mann–Whitney U | 41.000 | 45.000 | 33.000 | 50.000 | 42.000 |
| HGG n = 13, LGG n = 8 | P-value < | 0.589j | .817j | .169 | .885 | .469 |
| LGG vs. MET for Contralateral NAWM | Mann–Whitney U | 26.000 | 22.000 | 23.000 | 21.000 | 29.000 |
| LGG n = 8, MET n = 8 | P-value < | .529 | .294 | .344 | .248 | .753 |
Significance level of <.017 after Bonferroni–Sidàk correction :
aHGG n = 11, LGG n = 5;
bHGG n = 11, MET n = 9;
cLGG n = 5, MET n = 8;
dHGG n = 12, MET n = 9;
eLGG n = 7, MET n = 9;
fHGG n = 9, MET n = 3;
gHGG n = 13, MET n = 8;
hLGG n = 8, MET n = 8;
iHGG n = 12, MET n = 8;
jHGG n = 12, LGG n = 8.