Figure 2.

Sustained release of Mg²⁺ and Dex from the HA‐Pam‐Mg nanocomposite hydrogels. a) Cumulative release of Mg²⁺ from the HA‐Pam‐Mg hydrogels that were loaded with Dex via physical encapsulation (HA‐Pam‐Mg·Dex) or with DexP via the binding of DexP of Pam‐Mg NPs (HA‐Pam‐Mg‐DexP) in the PBS buffer (free of both Ca²⁺ and Mg²⁺). b) Cumulative release of Dex from the HA‐Pam‐Mg hydrogels in the PBS buffer. For ALP‐triggered Dex release, ALP (100 U mL⁻¹) was added on day 3. c) Schematic illustrations of the biomarker‐responsive release of Dex from HA‐Pam‐Mg‐DexP hydrogels via positive feedback circuit.